{"id":85914,"date":"2021-08-22T11:00:36","date_gmt":"2021-08-22T03:00:36","guid":{"rendered":"http:\/\/www.zhushiyao.com\/?p=85914"},"modified":"2021-08-22T11:01:18","modified_gmt":"2021-08-22T03:01:18","slug":"521e9acb58","status":"publish","type":"post","link":"http:\/\/www.zhushiyao.com\/?p=85914","title":{"rendered":"\u300a\u81ea\u7136\u300b\u5b50\u520a\uff1a\u71ac\u591c\u6bc1\u8111\u5b50\uff0c\u80a0\u83cc\u4e5f\u6709\u9505\uff01\u5317\u533b\u516d\u9662\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u7761\u7720\u5265\u593a\u4f1a\u5f15\u8d77\u80a0\u83cc\u7d0a\u4e71\uff0c\u4fc3\u708e\u4f24\u8111\uff0c\u5bfc\u81f4\u8ba4\u77e5\u529f\u80fd\u53d7\u635f\u4e28\u79d1\u5b66\u5927\u53d1\u73b0"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"box-sizing: border-box; font-style: normal; font-weight: 400; text-align: justify; font-size: 16px;\">\n<section style=\"font-size: 15px; line-height: 1.9; padding: 0px 20px; box-sizing: border-box;\">\n<p style=\"white-space: normal; margin: 0px; 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margin: 0px; padding: 0px; box-sizing: border-box;\">\u00a0<\/p>\n<p style=\"white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\">\u8fd1\u65e5\uff0c\u5317\u4eac\u5927\u5b66\u7b2c\u516d\u4eba\u6c11\u533b\u9662\u7684\u9646\u6797\u9662\u58eb\u7814\u7a76\u56e2\u961f\u5728\u300a\u81ea\u7136\u300b\u7684\u65d7\u4e0b\u5b50\u520a<em>Molecular Psychiatry<\/em>\u53d1\u8868\u91cd\u8981\u7814\u7a76\u6210\u679c\uff0c\u4ed6\u4eec\u53d1\u73b0<span style=\"color: #e8384a;\"><strong>\u7761\u7720\u5265\u593a\uff08SD\uff09\u5f15\u8d77\u80a0\u9053\u83cc\u7fa4\u7d0a\u4e71\uff0c\u4fc3\u8fdb\u708e\u75c7\u4fe1\u53f7\u901a\u8defTLR4\/NF-\u03baB\u7684\u6fc0\u6d3b\uff0c\u8bf1\u5bfc\u4e2d\u67a2\u795e\u7ecf\u708e\u75c7\u53ca\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u6d3b\u5316\uff0c\u6700\u7ec8\u5bfc\u81f4\u8ba4\u77e5\u529f\u80fd\u53d7\u635f<\/strong><\/span>[1]\u3002<\/p>\n<p style=\"white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\">\u00a0<\/p>\n<\/section>\n<section style=\"text-align: center; 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margin-bottom: 10px; box-sizing: border-box;\">\n<section style=\"max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 88%; height: auto; box-sizing: border-box;\"><img decoding=\"async\" style=\"vertical-align: middle; max-width: 100%; width: 100%; box-sizing: border-box;\" title=\"\u300a\u81ea\u7136\u300b\u5b50\u520a\uff1a\u71ac\u591c\u6bc1\u8111\u5b50\uff0c\u80a0\u83cc\u4e5f\u6709\u9505\uff01\u5317\u533b\u516d\u9662\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u7761\u7720\u5265\u593a\u4f1a\u5f15\u8d77\u80a0\u83cc\u7d0a\u4e71\uff0c\u4fc3\u708e\u4f24\u8111\uff0c\u5bfc\u81f4\u8ba4\u77e5\u529f\u80fd\u53d7\u635f\u4e28\u79d1\u5b66\u5927\u53d1\u73b0\" src=\"http:\/\/www.zhushiyao.com\/wp-content\/uploads\/2021\/08\/3-1629601236-1.png\" alt=\"\u300a\u81ea\u7136\u300b\u5b50\u520a\uff1a\u71ac\u591c\u6bc1\u8111\u5b50\uff0c\u80a0\u83cc\u4e5f\u6709\u9505\uff01\u5317\u533b\u516d\u9662\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u7761\u7720\u5265\u593a\u4f1a\u5f15\u8d77\u80a0\u83cc\u7d0a\u4e71\uff0c\u4fc3\u708e\u4f24\u8111\uff0c\u5bfc\u81f4\u8ba4\u77e5\u529f\u80fd\u53d7\u635f\u4e28\u79d1\u5b66\u5927\u53d1\u73b0\" width=\"100%\" \/><\/section>\n<\/section>\n<section style=\"font-size: 15px; 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line-height: 1.9; padding: 0px 20px; box-sizing: border-box;\">\n<p style=\"text-align: center; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">\u56fe\u6587\u6458\u8981\uff1a\u80a0\u9053\u83cc\u7fa4\u8c03\u8282\u7761\u7720\u5265\u593a\u540e\u7684\u514d\u75ab\u708e\u75c7\u53cd\u5e94\uff0c\u4fc3\u8fdbSD\u76f8\u5173\u7684\u8ba4\u77e5\u529f\u80fd\u53d7\u635f<br style=\"box-sizing: border-box;\" \/><\/span><\/p>\n<p style=\"white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\">\u00a0<\/p>\n<p style=\"white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\">\u4e0d\u8fc7\u8bdd\u8bf4\u56de\u6765\uff0c\u665a\u7761\u515a\u4eec\uff0c\u4efb\u4f55\u4ee5\u4f24\u8eab\u4f53\u4e3a\u524d\u63d0\u7684\u71ac\u591c\u7edd\u5bf9\u662f\u4e0d\u503c\u5f97\u71ac\u7684\u591c\uff0c\u8fd8\u662f\u517b\u6210\u826f\u597d\u7684\u7761\u7720\u4e60\u60ef\u5427\u3002\u53cd\u6b63\u5947\u70b9\u7cd5\u5df2\u7acb\u4e0bflag\uff1a\u4eca\u665a\u7edd\u4e0d\u71ac\u591c\uff01<\/p>\n<p style=\"font-size: 15px; white-space: normal; caret-color: #333333; text-size-adjust: auto; text-align: center;\">\u00a0<\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">\u53c2\u8003\u6587\u732e<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[1]. Wang Z, Chen WH, Li SX, et al. Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation.\u00a0Mol Psychiatry. 2021;10.1038\/s41380-021-01113-1. doi:10.1038\/s41380-021-01113-1<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[2]. Kreutzmann JC, Havekes R, Abel T, Meerlo P. Sleep deprivation and hippocampal vulnerability: changes in neuronal plasticity, neurogenesis and cognitive function.\u00a0Neuroscience. 2015;309:173-190. doi:10.1016\/j.neuroscience.2015.04.053<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[3]. Wang YH, Wang J, Chen SH, et al. Association of Longitudinal Patterns of Habitual Sleep Duration With Risk of Cardiovascular Events and All-Cause Mortality.\u00a0JAMA Netw Open. 2020;3(5):e205246. Published 2020 May 1. doi:10.1001\/jamanetworkopen.2020.5246<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[4]. Irwin MR. Sleep and inflammation: partners in sickness and in health.\u00a0Nat Rev Immunol. 2019;19(11):702-715. doi:10.1038\/s41577-019-0190-z<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[5]. Pearson-Leary J, Zhao C, Bittinger K, et al. The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats.\u00a0Mol Psychiatry. 2020;25(5):1068-1079. doi:10.1038\/s41380-019-0380-x<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[6]. An Q, Li C, Chen Y, et al. Scaffold hopping of agomelatine leads to enhanced antidepressant effects by modulation of gut microbiota and host immune responses.\u00a0Pharmacol Biochem Behav. 2020;192:172910. doi:10.1016\/j.pbb.2020.172910<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[7]. Koh A, De Vadder F, Kovatcheva-Datchary P, B\u00e4ckhed F. From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites.\u00a0Cell. 2016;165(6):1332-1345. doi:10.1016\/j.cell.2016.05.041<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[8]. Vinolo MA, Rodrigues HG, Nachbar RT, Curi R. Regulation of inflammation by short chain fatty acids.\u00a0Nutrients. 2011;3(10):858-876. doi:10.3390\/nu3100858<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[9]. Li JM, Yu R, Zhang LP, et al. Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids.\u00a0Microbiome. 2019;7(1):98. Published 2019 Jun 29. doi:10.1186\/s40168-019-0713-7<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[10]. Benedict C, Vogel H, Jonas W, et al. Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals.\u00a0Mol Metab. 2016;5(12):1175-1186. Published 2016 Oct 24. doi:10.1016\/j.molmet.2016.10.003<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[11]. Irwin MR, Wang M, Ribeiro D, et al. Sleep loss activates cellular inflammatory signaling.\u00a0Biol Psychiatry. 2008;64(6):538-540. doi:10.1016\/j.biopsych.2008.05.004<\/span><\/p>\n<p style=\"text-align: left; white-space: normal; margin: 0px; padding: 0px; box-sizing: border-box;\"><span style=\"font-size: 12px; color: #a0a0a0; box-sizing: border-box;\">[12]. Laugerette F, Alligier M, Bastard JP, et al. Overfeeding increases postprandial endotoxemia in men: Inflammatory outcome may depend on LPS transporters LBP and sCD14.\u00a0Mol Nutr Food Res. 2014;58(7):1513-1518. doi:10.1002\/mnfr.201400044<\/span><\/p>\n<\/section>\n<\/section>\n<\/div>\n\n\n<p>\u8f6c\u81ea\uff1ahttps:\/\/mp.weixin.qq.com\/s\/HDMm4Kr420dWTVwMsqsPmA<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0 \u5728\u73b0\u5982\u4eca\u7684\u5feb\u8282\u594f\u751f\u6d3b\u4e2d\uff0c\u71ac\u591c\u665a\u7761\u5df2\u7ecf\u6210\u4e3a\u5f53\u4ee3\u201c\u642c\u7816\u4eba\u201d\u7684\u751f\u6d3b\u6807\u7b7e\u3002\u201c\u62a5\u590d\u6027\u71ac\u591c\u201d\u3001\u201c\u670b\u514b\u517b\u751f\u201d\u3001\u201c\u8d8a\u665a\u8d8a\u55e8 &hellip; <a href=\"http:\/\/www.zhushiyao.com\/?p=85914\" class=\"more-link\">\u7ee7\u7eed\u9605\u8bfb<span class=\"screen-reader-text\">\u201c\u300a\u81ea\u7136\u300b\u5b50\u520a\uff1a\u71ac\u591c\u6bc1\u8111\u5b50\uff0c\u80a0\u83cc\u4e5f\u6709\u9505\uff01\u5317\u533b\u516d\u9662\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u7761\u7720\u5265\u593a\u4f1a\u5f15\u8d77\u80a0\u83cc\u7d0a\u4e71\uff0c\u4fc3\u708e\u4f24\u8111\uff0c\u5bfc\u81f4\u8ba4\u77e5\u529f\u80fd\u53d7\u635f\u4e28\u79d1\u5b66\u5927\u53d1\u73b0\u201d<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[16],"_links":{"self":[{"href":"http:\/\/www.zhushiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/85914"}],"collection":[{"href":"http:\/\/www.zhushiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.zhushiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.zhushiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.zhushiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=85914"}],"version-history":[{"count":2,"href":"http:\/\/www.zhushiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/85914\/revisions"}],"predecessor-version":[{"id":85936,"href":"http:\/\/www.zhushiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/85914\/revisions\/85936"}],"wp:attachment":[{"href":"http:\/\/www.zhushiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=85914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.zhushiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=85914"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.zhushiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=85914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}